Transforming Growth Factor-beta Type II Receptor

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.

Also Known As:

Receptor, Transforming Growth Factor-beta Type II; TGF-beta Type II Receptor; TGF-beta Type II Receptors; TGFBR2; TbetaR-II Kinase; Transforming Growth Factor-beta Type II Receptors; Type II TGF-beta Receptor; Type II TGF-beta Receptors; Kinase, TbetaR-II; Receptor, Transforming Growth Factor beta Type II; TGF beta Type II Receptor; TGF beta Type II Receptors; TbetaR II Kinase; Transforming Growth Factor beta Type II Receptor; Transforming Growth Factor beta Type II Receptors; Type II TGF beta Receptor; Type II TGF beta Receptors

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Transforming Growth Factor-beta Type II Receptor: 887
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Transforming Growth Factor beta Receptors: 836
        Transforming Growth Factor-beta Type II Receptor: 887
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Transforming Growth Factor beta Receptors: 836
        Transforming Growth Factor-beta Type II Receptor: 887
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Transforming Growth Factor-beta Type II Receptor: 887

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Disease

Drug/Important Bio-Agent (IBA)